Papers

Recent papers to highlight

Zhang KK, Burns CM, Skinner ME, Lombard DB, Miller RA, Endicott SJ. PTEN is both an activator and a substrate of chaperone-mediated autophagy. J Cell Biol. 2023 Sep 4;222(9):e202208150. doi: 10.1083/jcb.202208150. Epub 2023 Jul 7.PMID: 37418003

Zhang KK, Zhang P, Kodur A, Erturk I, Burns CM, Kenyon C, Miller RA, Endicott SJ. LAMP2A, and other chaperone-mediated autophagy related proteins, do not decline with age in genetically heterogeneous UM-HET3 mice. Aging (Albany NY). 2023 Jun 13;15(11):4685-4698. doi: 10.18632/aging.204796. Epub 2023 Jun 13. PMID: 37315291

Shi X, Endicott SJ, Miller RA. Regulation of mTOR complexes in long-lived growth hormone receptor knockout and Snell dwarf mice. Aging (Albany NY). 2022 Mar 19;14(6):2442-2461. doi: 10.18632/aging.203959. Epub 2022 Mar 19. PubMed PMID: 35305083; PubMed Central PMCID: PMC9004569.

Endicott SJ, Monovich AC, Huang EL, Henry EI, Boynton DN, Beckmann LJ, MacCoss MJ, Miller RA. Lysosomal targetomics of ghr KO mice shows chaperone-mediated autophagy degrades nucleocytosolic acetyl-coA enzymes. Autophagy. 2022 Jul;18(7):1551-1571. doi: 10.1080/15548627.2021.1990670. Epub 2021 Dec 29. PubMed PMID: 34704522; PubMed Central PMCID: PMC9298451.

Endicott SJ, Ziemba ZJ, Beckmann LJ, Boynton DN, Miller RA. Inhibition of class I PI3K enhances chaperone-mediated autophagy. J Cell Biol. 2020 Dec 7;219(12). doi: 10.1083/jcb.202001031. PubMed PMID: 33048163; PubMed Central PMCID: PMC7557678.

Endicott SJ, Boynton DN Jr, Beckmann LJ, Miller RA. Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy. Autophagy. 2021 Mar;17(3):612-625. doi: 10.1080/15548627.2020.1725378. Epub 2020 Feb 12. PubMed PMID: 32013718; PubMed Central PMCID: PMC8032237.